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The Clark Building is located on Liberty Avenue at the corner of Seventh Street in the heart of the cultural district. The central downtown location allows for easy access to public transportation, parking and major highways.

The cultural district's continued growth has been strongly supported by the City of Pittsburgh. An area of great activity including theaters, restaurants and galleries, the cultural district is home to Heinz Hall, the Benedum Center and the O'Reilly Theater, and is within walking distance of the new Convention Center, PNC Park and Heinz Field.